Akai N, Igaki T and *Ohsawa S "Exocytosis coordinates epithelial cell-turnover in Drosophila ribosomal protein mutants" bioRxiv 2023 Dec 28 [Online]
Peterson W et al. "Flow zoometry of Drosophila" bioRxiv 2024 Apr 4 [Online]
2025年
Li J, Taniguchi K, Ye W, Kondo S, Kobayashi T, Matsuyama M, Saito K, Ohsawa S and *Igaki T "Epithelial cell-fate switch triggering ectopic ligand-receptor-mediated JAK-STAT signaling promotes tumorigenesis in Drosophila" iScience 2025 (in press)
Zang Y, Yoshimoto M and *Igaki T "Programmed cell senescence is required for sensory organ development in Drosophila" iScience 2025 Mar 21;28 (3) (in press)
*Goda K, Igaki T, Kuhn B, Mizushima N, Nagai T, Nakagawa A, Osumi N, Shen A, Sonoshita M and Yanagisawa M "Japan can be a science heavyweight once more — if it rethinks funding" Nature 2025 Feb 11;638(8050):318-320 [Pubmed]
2024年
Kakemura B, and *Igaki T "Blockade of Crk eliminates Yki/YAP-activated tumors via JNK-mediated apoptosis in Drosophila" Commun Biol 2024 Sep 28;7(1) [Pubmed]
Nagata R and *Igaki T. "Cell competition: emerging signaling and unsolved questions" FEBS Lett. 2024 Feb;598(4):379-389 [PubMed] (Review)
Kitamura D, Taniguchi K, Nakamura M and *Igaki T. "In vivo evidence for homeostatic regulation of ribosomal protein levels in Drosophila" Cell Structure and Function 2024 Jan 16;49(1):11-20. [PubMed]
2023年
*Taniguchi K and *Igaki T. "Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis" PLOS Genetics 2023 Mar 27;19(3):e1010684 [PubMed]
*Niwa R, Sato M and Igaki T. "Editorial note: flying high in Japan" Fly 2023 Mar 6. [Online] (Editorial)
2022年
Enomoto M and Igaki T. "Cell-cell interactions that drive tumorigenesis in Drosophila" Fly 2022 Nov;16(1):367-381. [PubMed] (Review)
Wang Z, Xia X, Li J and Igaki T. "Tumor elimination by clustered microRNAs miR-306 and miR-79 via non-canonical activation of JNK signaling" eLife 2022 Oct 12;11:e77340 [PubMed]
Nagata R, Akai N, Kondo S, Saito K, Ohsawa S and Igaki T. "Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila" Current Biology 2022 Feb 07 [PubMed]
Ochi N, Nakamura M, Nagata R, Wakasa N, Nakano R and Igaki T. "Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α" PLOS Genetics 2021 Dec 6;17(12):e1009958 [PubMed]
Cong B, Nakamura M, Sando Y, Kondo T, Ohsawa S and Igaki T. "JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila" PLOS Genetics 2021 Nov 15;17(11):e1009893 [PubMed]
#Enomoto M, Takemoto D and #Igaki T. "Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila" Developmental Cell 2021 Aug 9;56(15):2223-2236.e5. [PubMed]
Ito T and Igaki T. "Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence" Science Signaling 2021 Jun 1;14(685), eaaz3578 [PubMed]
*Akai N, *#Ohsawa S, Sando Y and #Igaki T. "Epithelial cell turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants" PLOS Genetics 2021 Jan 28;17(1):e1009300 [PubMed]
2020年
Kanda H and Igaki T. "Mechanism of tumor-suppressive cell competition in flies" Cancer Science 2020 Jul 17; 111:3409-3415 [PubMed] (Review)
Sanaki Y, Nagata R, Kizawa D, Léopold P and Igaki T. "Hyperinsulinemia drives epithelial tumorigenesis by abrogating cell competition" Developmental Cell 2020 May 18;53(4):379-389 [PubMed]
Developmental Cell "Previews" by S. Hirabayashi & R. Cagan, Selected for Cover of the issue
Iida C, Ohsawa S, Taniguchi K, Yamamoto M, Morata G and Igaki T. "JNK-mediated Slit-Robo signaling facilitates epithelial wound repair by extruding dying cells" Scientific Reports 2019 Dec 20;9(1) [PubMed]
Nagata R, Nakamura M, Sanaki Y and Igaki T. "Cell competition is driven by autophagy" Developmental Cell 2019 Oct 7;51(1):99-112 [PubMed]
Developmental Cell "Previews" by C. Dillard & T.E. Rusten
2018年
Nagata R and Igaki T. "Cell competition: Emerging mechanisms to eliminate neighbors" Dev Growth Differ 2018 [PubMed]（Review）
O'Donnell MA. "Tatsushi Igaki: Flying up the research summits." Journal of Cell Biology 2018 [PubMed]
Enomoto M, Siow C and Igaki T. "Drosophila As a Cancer Model" Adv Exp Med Biol 2018 [PubMed]
Tsuboi A, Ohsawa S, Umetsu D, Sando Y, Kuranaga E, Igaki T. and Fujimoto K "Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology" Current Biology 2018 Jun 11 [PubMed]
Katsukawa M, Ohsawa S, Zhang L, Yan Y and Igaki T. "Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila" Current Biology 2018 May 15 [PubMed]
Cong B, Ohsawa S and Igaki T. "JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila." Oncogene 2018 Mar 14 [PubMed]
Akai N, #Igaki T and #Ohsawa S. "Wingless signaling regulates winner/loser status in Minute cell competition." Genes to Cells 2018 Feb 12 [PubMed]
Ohsawa S, Vaughen J and Igaki T. "Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis." Developmental Cell 2018 Feb 5;44 (3):284-296 [PubMed] (Review)
2017年
Vaughen J and Igaki T. "Breaking Down Neighbors to Fuel Tumorigenesis" Developmental Cell 2017 Feb 6;40 (3):219-220 [PubMed] (Review)
*Yamamoto M, *Ohsawa S, Kunimasa K and Igaki T. "The ligand Sas and its receptor PTP10D drive tumor-suppressive cell competition" Nature 2017 Feb 9;542 (7640):246-250 (*equal contribution) [PubMed]
Vaughen J and Igaki T. "Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia" Developmental Cell 2016 Dec 19;39 (6):683-695 [PubMed]
Ito T and Igaki T "Dissecting cellular senescence and SASP in Drosophila" Inflammation and Regeneration 2016 Sep 17;36:25 [BioMed link](Review)
Nakamura M and Igaki T "Induction and Detection of Oncogene-Induced Cellular Senescence in Drosophila" Methods in Molecular Biology 2016, pp211-218 [PubMed]
Ohsawa S and Igaki T "Non-autonomous Tumor Progression by Oncogenic Inflammation" Chronic Inflammation 2016, pp211-222 [Springer link] (Review)
Nishikawa S, Takamatsu A, Ohsawa S, Igaki T "Mathematical model for cell competition: predator-prey interactions at the interface between two groups of cells in monolayer tissue" J. Theoretical Biology 2016 Sep 7;404:40-50 [PubMed]
2015年
Igaki T "Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki" Disease Models and Mechanisms 2015 8: 1491-1494 [PDF][PubMed] (Interview)
Enomoto M, Vaughen J, Igaki T "Non-autonomous overgrowth by oncogenic niche cells: cellular cooperatrion and competition in tumorigenesis" Cancer Science 2015 Sep 12 [PubMed](Review)
Enomoto M, Kizawa D, Ohsawa S, Igaki T "JNK signaling is coverted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity" Developmental Biology 2015 Jul 15;403(2):162-71 [PubMed]
2014年
*Nakamura M, *Ohsawa S, Igaki T "Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila" Nature Communications 2014 Oct27;5:5264 [PubMed] (*equal contribution)
*Takino K, *Ohsawa S, Igaki T "Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila" Developmental Biology 2014 Nov 1;395(1):19-28 [PubMed](*equal contribution)
Ohsawa S,Takemoto D, Igaki T "Dissecting tumor heterogeneity in flies: genetic basis of interclonal oncogenic coorperation" J. Biochem. 2014 Sep;156(3):129-36 [Pub Med] (Review)
Igaki T, Miura M "The Drorosophila TNF ortholong Eiger: Emerging physiological roles and evolution of the TNF system." Semin. Immunol. 2014, S1044-5323 (2014) [Pub Med] (Review)
Kunimasa K, Ohsawa S, Igaki T "Cell Competition: The Struggle for Existence in Multicellular Communities" New Principles in Developmental Processes 2014, pp27-40 [Springer Link] (Review)
2013年
Enomoto M, Igaki T "Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila" EMBO Reports 14,65-72(2013) [PubMed]
2012年
Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T. "Mitochondrial defect drives non-autonomous tumor progression through Hippo signaling in Drosophila" Nature 490, 547-551 (2012) [PubMed]
Kanda H, Igaki T, Okano H, Miura M "Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death." Proc. Natl. Acad. Sci. USA 108, 18977-18982 (2011) [PubMed]
Enomoto M, Igaki T. "Deciphering tumor-suppressor signaling in flies: genetic link between Scrib/Dlg/Lgl and the Hippo pathway" J. Genet. Genom. 38, 461-70 (2011) [PubMed] (Review)
Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T. "Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila" Developmental Cell 20, 315-328 (2011) [PubMed]
Igaki T, Kanda H, Okano H, Xu T, Miura M. "Eiger and wengen: The Drosophila orthologs of TNF/TNFR" Adv. Exp. Med. Biol. 691, 45-50 (2011) [PubMed] (Review)
2010年
Ohsawa S, Hamada S, Kuida K, Yoshida H, Igaki T, Miura M. "Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity" Proc. Natl. Acad. Sci. USA. 107, 13366-13371 (2010) [PubMed]a
2009年
Igaki T “Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling” Apoptosis 14, 1021-1028 (2009) [PubMed] (Review)
Igaki T, Pastor-Pareja JC, Aonuma H, Miura M, Xu T. “Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila” Developmental Cell 16, 458-465 (2009) [PubMed]
2007年
Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu, T. "Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila” Developmental Cell 13, 446-454 (2007) [PubMed]
Srivastava A, Pastor-Pareja JC, Igaki T, Pagliarini R, Xu T. “Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion” Proc. Natl. Acad. Sci. USA. 104, 2721-2726 (2007) [PubMed]
*Igaki T, *Suzuki Y, Tokushige N, Aonuma H, **Takahashi R, **Miura M. “Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila” Biochem. Biophys. Res. Commun. 356, 993-997 (2007) [PubMed] (*equal contribution)
2006年
Igaki T, Pagliarini R, Xu T “Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila” Current Biology 16, 1139-1146 (2006) [PubMed]
2005年
Senoo-Matsuda N, Igaki T, Miura M “Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila” EMBO J. 24, 2700-2713 (2005) [PubMed]
Kanuka H, Hiratou T, Igaki T, Kanda H, Kuranaga E, Sawamoto K, Aigaki T, Okano H, Miura M "Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity" Biochim. Biophys. Acta. 1726, 225-237 (2005) [PubMed]
2004年
Igaki T, Miura M "Role of Bcl-2 family members in invertebrates" Biochim. Biophys. Acta. 1644, 73-81 (2004) (Review) [PubMed]
2003年
Kanuka H, Kuranaga E, Hiratou T, Igaki T, Nelson B, Okano H, Miura M "Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila” Proc. Natl. Acad. Sci. USA 100, 11723-11728 (2003) [PubMed]
2002年
Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M “Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway” EMBO J. 21, 3009-3018 (2002) [PubMed]
Igaki T, Yamamoto-Goto Y, Tokushige N, Kanda H, Miura M “Downregulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by DARK and DRONC.” J. Biol. Chem. 277, 23103-23106 (2002) [PubMed]
Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M "Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.” Nature Cell Biology 4, 705-10 (2002) [PubMed]
Kanda H, Igaki T, Kanuka H, Yagi T, Miura M “Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling.” J. Biol. Chem. 277, 28372-28375 (2002) [PubMed]
2000年
Igaki T, Kanuka H, Inohara N, Sawamoto K, Nunez G, Okano H, Miura M “Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death.” Proc. Natl. Acad. Sci. USA 97, 662-667 (2000) [PubMed]
Xu T, Pagliarini R, Igaki T “A genetic screen in Drosophila for metastatic behavior” United States Patent 20060288429 (2006)
Xu T, Pagliarini R, Igaki T “A genetic screen in Drosophila for metastatic behavior” International Patent WO 2005/035729 A3 (2005) International Publication Date: April 21 (2005)